Insights into the genetic variation profile of tprK in Treponema pallidum during the development of natural human syphilis infection.
Dan LiuMan-Li TongYong LinLi-Li LiuLi-Rong LinTian-Ci YangPublished in: PLoS neglected tropical diseases (2019)
The identification of different profiles of the tprK gene in primary and secondary syphilis patients indicated that the tprK gene of T. pallidum undergoes constant variation to result in the best adaptation to the host. The highly stable peptides found in V1 are likely promising potential vaccine components. The highly heterogenetic regions (e.g., V6) could help to understand the role of tprK in immune evasion.
Keyphrases
- end stage renal disease
- human immunodeficiency virus
- men who have sex with men
- ejection fraction
- endothelial cells
- genome wide
- newly diagnosed
- copy number
- peritoneal dialysis
- genome wide identification
- climate change
- patient reported outcomes
- hepatitis c virus
- dna methylation
- gene expression
- pluripotent stem cells
- hiv infected