ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels.

Yang Lin Chang-Hyun Gil Kimihiko BannoMasataka YokoyamaMatthew WingoEllen GoNutan PrasainYing Liu Takashi Hato Hisamichi Naito Taku WakabayashiMusia SominskaiaMeng GaoKevin ChenFuqiang GengJesus Maria Gomez SalineroSisi ChenW Christopher ShelleyMomoko Yoshimoto Sergio Li CalziMichael P MurphyKyoji Horie Maria B Grant Ryan Schreiner David RedmondDavid P BasileShahin Rafii Mervin C Yoder

Published in: Circulation (2024)

These results are the first to establish that a single prospective marker identifies CRECs in mice and human individuals, which holds promise to provide new cell therapies for repair of damaged vessels in patients with endothelial dysfunction.

Keyphrases

endothelial cells
high glucose
single cell
vascular endothelial growth factor
cell therapy
genome wide
big data
high fat diet induced
wild type
pluripotent stem cells
type diabetes
metabolic syndrome
insulin resistance
skeletal muscle
mesenchymal stem cells