Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers.
Sofia B CarvalhoA Raquel FortunaMichael W WolffCristina PeixotoPaula M AlvesUdo ReichlManuel Jt CarrondoPublished in: Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) (2017)
Use of SCMA represents a significant improvement compared with conventional ion exchanger membrane adsorbers. As the method proposed is easily scalable and reduces the number of steps required compared with conventional purification methods, SCMA could qualify as a generic platform for purification of VLP-based influenza vaccines. © 2017 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.