Significant polyomic and functional upregulation of the PAPP-A/IGFBP-4/5/IGF-1 axis in chronic rhinosinusitis with nasal polyps.

Sarina Katrin MüllerAngela L NoceraAlan WorkmanTowia LibermannSimon T DillonAchim StegmannJochen WurmHeinrich IroOlaf WendlerBenjamin S Bleier

Published in: International forum of allergy & rhinology (2020)

Upregulated tissue and exosomal PAPP-A signaling is significantly associated with CRSwNP and may be an important factor in the promotion of epithelial proliferation and polyp growth. These data lend further support to the emerging concept of exosomal functional and polyomic analyses as a method to study sinonasal pathology.

Keyphrases

chronic rhinosinusitis
signaling pathway
electronic health record
cell proliferation
poor prognosis
pi k akt
machine learning