Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line.

Haruto UchinoMasaki ItoKen KazumataYuka HamaShuji HamauchiShunsuke TerasakaHidenao SasakiKiyohiro Houkin

Published in: BMC medical genomics (2018)

Our MMD-discordant monozygotic twin-based study confirmed a novel circulating microRNA signature in MMD as a potential diagnostic biomarker minimally confounded by genetic heterogeneity. The novel circulating microRNA signature can contribute for the future functional microRNA analysis to find new diagnostic and therapeutic target of MMD.

Keyphrases

poor prognosis
endothelial cells
dna methylation
risk assessment
copy number
preterm birth