Anti-inflammatory drugs prevent memory and hippocampal plasticity deficits following initial binge-like alcohol exposure in adolescent male rats.
Chloé DeschampsFloriane UyttersprotMargot DebrisConstance MariéGrégory FouquetIngrid MarcqCatherine VilpouxMickael NaassilaOlivier PierrefichePublished in: Psychopharmacology (2022)
Two binge-like ethanol exposures during adolescence in rat involved neuroinflammation leading to changes in TLR4 expression and in GluN2B functioning inducing disturbances in synaptic plasticity and cognitive deficits. Anti-inflammatory drugs are good candidates to prevent brain function and memory deficits induced by few binge-drinking episodes.
Keyphrases
- anti inflammatory drugs
- traumatic brain injury
- cerebral ischemia
- working memory
- poor prognosis
- alcohol consumption
- young adults
- toll like receptor
- inflammatory response
- depressive symptoms
- mental health
- immune response
- oxidative stress
- air pollution
- lipopolysaccharide induced
- white matter
- resting state
- cognitive impairment
- lps induced
- functional connectivity
- subarachnoid hemorrhage
- nuclear factor