Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis.

Bryan A JohnsonXuping XieBirte KalveramKumari G LokugamageAntonio MuruatoJing ZouXianwen ZhangTerry JuelichJennifer K SmithLihong ZhangNathen BoppCraig SchindewolfMichelle VuAbigail VanderheidenDaniele SwetnamJessica A PlantePatricia AguilarKenneth S PlanteBenhur LeeScott C WeaverMehul S Suthar Andrew L RouthPing RenZhiqiang KuZhiqiang AnKari DebbinkPei Yong ShiAlexander N FreibergVineet D Menachery

Published in: bioRxiv : the preprint server for biology (2020)

A deletion of the furin cleavage site in SARS-CoV-2 amplifies replication in Vero cells, but attenuates replication in respiratory cells and pathogenesis in vivo. Loss of the furin site also reduces susceptibility to neutralization in vitro .

Keyphrases

sars cov
induced apoptosis
cell cycle arrest
respiratory syndrome coronavirus
dna binding
signaling pathway
cell death
transcription factor
pi k akt