A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.

Janet S SoulAnn M BerginChristian StoppBreda HayesAvantika SinghCarmen R FortunoDeirdre O'ReillyKalpathy KrishnamoorthyFrances E JensenValerie RofebergMin DongAlexander A VinksDavid WypijKevin J Staleynull null

Published in: Annals of neurology (2020)

Although definitive proof of efficacy awaits an appropriately powered phase 3 trial, this randomized, controlled, multicenter trial demonstrated an additional reduction in seizure burden attributable to bumetanide over phenobarbital without increased serious adverse effects. Future trials of bumetanide and other drugs should include a control group and balance seizure severity. ANN NEUROL 2021;89:327-340.

Keyphrases

phase iii
double blind
placebo controlled
phase ii
clinical trial
study protocol
open label
temporal lobe epilepsy
randomized controlled trial
current status