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A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors.

Kristýna NěmejcovaMichaela Kendall BártůRomana MichálkováJana DrozenováPavel FabianOluwole FadareJitka HausnerováJan LacoRadoslav MatějGábor MéhesNaveena SinghSimona StolnicuPetr ŠkapaMarián ŠvajdlerIvana StružinskáDavid CibulaRoman KocianSigurd F LaxW Glenn McCluggagePavel Dundr
Published in: Diagnostic pathology (2023)
Concerning differential diagnosis our results imply that despite the differences in expression in the different ovarian tumor types, the practical value for diagnostic purposes is limited. Contrary to other solid tumors, we did not find prognostic significance of IMP3 in ovarian cancer, with the exception of RFS in low grade serous carcinomas. However, the high expression of IMP2 and IMP3 could be of predictive value in ovarian carcinomas since IMP proteins are potential therapeutical targets.
Keyphrases
  • high grade
  • low grade
  • poor prognosis
  • binding protein
  • human health