Three-dimensional models of Mycobacterium tuberculosis proteins Rv1555, Rv1554 and their docking analyses with sildenafil, tadalafil, vardenafil drugs, suggest interference with quinol binding likely to affect protein's function.
Pallabini DashM Bala DivyaLalitha GuruprasadKunchur GuruprasadPublished in: BMC structural biology (2018)
The predicted binding sites of the drugs is likely to affect the above M.tb proteins function as quinol binding is known to be essential for electron transfer function during anaerobic respiration in the homologous E.coli protein complex. Therefore, sildenafil and related drugs currently used in the treatment of male erectile dysfunction targeting the human phosphodiesterase 5 enzyme may be evaluated for their plausible role as repurposed drugs to treat human tuberculosis.
Keyphrases
- mycobacterium tuberculosis
- endothelial cells
- pulmonary tuberculosis
- protein protein
- electron transfer
- pulmonary hypertension
- binding protein
- pulmonary arterial hypertension
- induced pluripotent stem cells
- escherichia coli
- pluripotent stem cells
- microbial community
- dna damage
- amino acid
- dna repair
- small molecule
- oxidative stress
- heavy metals
- adverse drug