Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis.
Lucien G J CayerArun SurendranTobias K KarakachHarold M AukemaAmir RavandiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.
Keyphrases
- aortic valve
- endothelial cells
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- induced pluripotent stem cells
- aortic stenosis
- mesenchymal stem cells
- pluripotent stem cells
- atrial fibrillation
- oxidative stress
- bone marrow
- heart failure
- early onset
- left ventricular
- coronary artery disease
- ejection fraction
- drug induced