A comprehensive review of 30 years of pediatric clinical trial radiotherapy dose constraints.

April VassantachartArthur J OlchMarjorie JonesChristophe MarquesCécile RonckersLouis S ConstineJohn H MaduroCharlotte de BoerKenneth K Wong

Published in: Pediatric blood & cancer (2023)

Review of pediatric dose-volume constraints in clinical trials showed substantial variability for all OAR. Continued efforts focused on standardization of OAR dose constraints and risk profiles are essential to increase consistency of protocol outcomes and ultimately to reduce radiation toxicities in the pediatric population.

Keyphrases

clinical trial
randomized controlled trial
early stage
phase ii
open label
study protocol
radiation therapy
squamous cell carcinoma
double blind
phase iii
quality improvement
weight loss