FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway.

Cheng-Cao SunWei ZhuShu-Jun LiWei HuJian ZhangYue ZhuoHan ZhangJuan WangYu ZhangShao-Xin HuangQi-Qiang HeDe-Jia Li

Published in: Genome medicine (2020)

In summary, our present research revealed the oncogenic roles of LINC00301 in clinical specimens as well as cellular and animal experiments, illustrating the potential roles and mechanisms of the FOXC1/LINC00301/EZH2/EAF2/pVHL/HIF1α and FOXC1/LINC00301/miR-1276/HIF1α pathways, which provides novel insights and potential theraputic targets to NSCLC.

Keyphrases

long non coding rna
long noncoding rna
poor prognosis
cell proliferation
endothelial cells
small cell lung cancer
stem cells
signaling pathway
risk assessment
single cell
tyrosine kinase
ultrasound guided