Critical Role of Notch-1 in Mechanistic Target of Rapamycin Hyperactivity and Vascular Inflammation in Patients With Takayasu Arteritis.

Wanwan JiangMengyao SunYing WangMing ZhengZixin YuanShixiong MaiXin ZhangLonghai TangXiyu LiuChunhong WangZhenke Wen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Expression of Notch-1 is elevated in CD4+ T cells from TA patients, resulting in mTORC1 hyperactivity and proinflammatory T cell differentiation. Targeting Notch-1 is a promising therapeutic strategy for the clinical management of TA.

Keyphrases

end stage renal disease
cell proliferation
ejection fraction
poor prognosis
chronic kidney disease
newly diagnosed
oxidative stress
peritoneal dialysis
patient reported outcomes
binding protein
long non coding rna