Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer.

Seong Yun LeeJunyoung ParkSang Beom Seo

Published in: Genes & genomics (2024)

TIP60 plays a crucial role in the regulation of HDAC3 transcription, thereby influencing cell proliferation and apoptosis in colon cancer. Consequently, TIP60 may function as a tumor suppressor by inhibiting HDAC3 expression in colon cancer cells.

Keyphrases

histone deacetylase
cell proliferation
transcription factor
poor prognosis
oxidative stress
endoplasmic reticulum stress
signaling pathway
cell death
cell cycle
gene expression
long non coding rna