Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2.

Yuko YamaguchiChiharu TayamaJunko TomikawaRina AkaishiHiromi KamuraKentaro MatsuokaNorio WakeHisanori MinakamiKiyoko KatoTakahiro YamadaKazuhiko NakabayashiKenichiro Hata

Published in: Clinical epigenetics (2019)

Placental epimutation at H19-DMR was observed among common pregnancy complication cases at the frequency of 1.5% (3 out of 202 cases examined), but not in 68 normal pregnancy cases examined. Alteration of H19/IGF2 expression patterns due to hypomethylation of H19-DMR may have been involved in the pathogenesis of pregnancy complications in these cases.

Keyphrases

preterm birth
pregnancy outcomes
poor prognosis
binding protein
risk factors
pi k akt
pregnant women
signaling pathway