Differential placental ceramide levels during gestational diabetes mellitus (GDM).
Juan F MejiaKelsey M HirschiKary Y F TsaiMatthew G LongBenton C TullisEliza E K BitterBenjamin T BikmanPaul R ReynoldsJuan A ArroyoPublished in: Reproductive biology and endocrinology : RB&E (2019)
Our findings confirm the presence of ceramide in the human placenta of control and GDM patients. Furthermore, we conclude that ceramide is increased in the placental trophoblast during insulin treatment and that its upregulation correlates with elevated NFAT5, SMIT, increased apoptosis and decreased trophoblast mitochondrial respiration.
Keyphrases
- end stage renal disease
- oxidative stress
- ejection fraction
- endothelial cells
- newly diagnosed
- type diabetes
- chronic kidney disease
- pregnant women
- cell death
- prognostic factors
- cell proliferation
- endoplasmic reticulum stress
- peritoneal dialysis
- signaling pathway
- cell cycle arrest
- poor prognosis
- insulin resistance
- nuclear factor
- immune response
- metabolic syndrome
- pregnancy outcomes