A 5-hydroxymethylcytosine-based non-invasive model for early detection of colorectal carcinomas and advanced adenomas: the METHOD-2 study.

Wenju Chang Sheng Zhang Baoqing Jia Ke-Feng Ding Zhizhong Pan Guoqiang Su Weiyuan Zhang Tianyu Liu Yun-Shi Zhong Guodong He Li Ren Ye Wei Dongdong Li Xiao-Long Cui Jun Yang Yixiang Shi Marc Bissonnette Chuan He Tripti Khare Jia Fan Jianmin Xu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Genome-wide mapping of 5hmC in cfDNA shows the promise as a highly sensitive and specific non-invasive blood test to be integrated in screening programs for improving early detection of CRC and high-risk AA.

Keyphrases

genome wide
public health
high resolution
high grade
living cells
fluorescent probe
mass spectrometry
single molecule