A 5-hydroxymethylcytosine-based non-invasive model for early detection of colorectal carcinomas and advanced adenomas: the METHOD-2 study.
Wenju ChangSheng ZhangBaoqing JiaKe-Feng DingZhizhong PanGuoqiang SuWeiyuan ZhangTianyu LiuYun-Shi ZhongGuodong HeLi RenYe WeiDongdong LiXiao-Long CuiJun YangYixiang ShiMarc BissonnetteChuan HeTripti KhareJia FanJianmin XuPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Genome-wide mapping of 5hmC in cfDNA shows the promise as a highly sensitive and specific non-invasive blood test to be integrated in screening programs for improving early detection of CRC and high-risk AA.