SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.

Pamela BecheriniIrene CaffaFrancesco PiacentePatrizia DamonteValerio G VelloneMario PassalacquaAndrea BenziTommaso BonfiglioDaniele ReverberiAmr KhalifaMoustafa GhanemAna GuijarroLuca TagliaficoMarzia SucameliAngelica PersiaFiammetta MonacelliMichele CeaSantina BruzzoneSilvia RaveraAlessio Nencioni

Published in: Cancer & metabolism (2021)

Via its enzymatic activity, SIRT6 enhances PDH expression and activity, OXPHOS, ATP/AMP ratio, and intracellular calcium concentration, while reducing AMPK activation, in BC cells. Thus, overall, SIRT6 inhibition appears as a viable strategy for preventing or treating BC.

Keyphrases

protein kinase
oxidative stress
induced apoptosis
ischemia reperfusion injury
poor prognosis
cell cycle arrest
skeletal muscle
hydrogen peroxide
high fat diet induced
cell death
binding protein
signaling pathway
young adults