Sex-specific biobehavioral regulation of persistent inflammatory pain by alcohol.

Jessica A Cucinello-RaglandNoor H AlrashedSumin LeeErin C DavisKimberly N EdwardsScott Edwards

Published in: Alcoholism, clinical and experimental research (2023)

These data suggest that individuals may develop tolerance to alcohol's ability to alleviate both somatic and negative motivational symptoms of chronic pain over time. We also discovered sex-specific neuroadaptations in protein kinase A (PKA)-dependent phosphorylation of GluR1 subunits and extracellular signal-regulated kinase (ERK 1/2) phosphorylation in nociceptive brain centers of animals receiving an alcohol challenge 1 week post-CFA. Together these findings illustrate a sex-specific regulation of behavioral and neurobiological indices of persistent pain by alcohol.

Keyphrases

chronic pain
protein kinase
pain management
alcohol consumption
neuropathic pain
electronic health record
gene expression
randomized controlled trial
spinal cord injury
tyrosine kinase
copy number
transcription factor
big data
white matter
resting state
genome wide
brain injury
dna methylation
machine learning