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Effects of Circulating HMGB-1 and Histones on Cardiomyocytes-Hemadsorption of These DAMPs as Therapeutic Strategy after Multiple Trauma.

Birte WeberIna LacknerMeike BaurGiorgio FoisFlorian GebhardIngo MarziHubert SchrezenmeierBorna ReljaMiriam Kalbitz
Published in: Journal of clinical medicine (2020)
Danger associated molecular patterns such as HMGB-1 and extracellular histones impair human CM in vitro. A hemadsorption filter could be a therapeutic option to reduce high concentrations of histones.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • high glucose
  • pluripotent stem cells