Treatment satisfaction, safety, and effectiveness of adding methotrexate to adalimumab in psoriasis patients responding sub-optimally to adalimumab in a real-world setting.
Kim A PappMelinda J GooderhamL E AlbrechtM-A RaymondC W LyndePublished in: The British journal of dermatology (2021)
an inadequate response to biologics may reach 30% in psoriasis patients.1,2 In other inflammatory diseases, a positive effect of adding methotrexate (MTX) to adalimumab has been reported.3,4 In this real-world, Canadian multicenter, single-arm, phase IIIb, open-label study, sub-optimal responders who have been receiving adalimumab for ≥16 weeks, who had a Physician's Global Assessment (PGA) ≥ 3 and Psoriasis Area Severity Index (PASI) ≥ 5, continued to self-administer adalimumab (40 mg every other week). Oral MTX was added (10 to 25 mg per week as per investigator's decision and could vary throughout the length of study) as well as folic acid (1-mg tablet daily) for 24 weeks.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- juvenile idiopathic arthritis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- open label
- randomized controlled trial
- clinical trial
- emergency department
- prognostic factors
- high dose
- systematic review
- peritoneal dialysis
- physical activity
- squamous cell carcinoma
- primary care
- ulcerative colitis
- patient reported outcomes
- hidradenitis suppurativa
- oxidative stress
- radiation therapy
- low dose
- decision making
- study protocol
- gestational age
- rectal cancer