Virus-like particles for vaccination against cancer.
Mona O MohsenDaniel E SpeiserAlexander KnuthMartin F BachmannPublished in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology (2019)
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus-like particle-based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of several infectious diseases and expectedly preventing cervical cancer caused by human papilloma virus. In contrast to these broad successes of disease prevention, therapeutic cancer vaccines remain to demonstrate clinical benefit. Yet, several preclinical and clinical trials have revealed promising results and are paving the way for medical breakthroughs. This study reviews and discusses the recent preclinical development and clinical trials in this field. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
Keyphrases
- clinical trial
- papillary thyroid
- immune response
- squamous cell
- infectious diseases
- healthcare
- endothelial cells
- magnetic resonance
- randomized controlled trial
- stem cells
- magnetic resonance imaging
- cell therapy
- computed tomography
- mesenchymal stem cells
- high resolution
- squamous cell carcinoma
- bone marrow
- mass spectrometry
- open label
- atomic force microscopy
- induced pluripotent stem cells
- contrast enhanced