CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.
Shuyu PiaoJun Wan LeeHarsha NagarSaet-Byel JungSujeong ChoiSeonhee KimIkjun LeeSung-Min KimNara ShinYu Ran LeeSang Do LeeJin Bong ParkKaikobad IraniMinho WonGang Min HurByeong Hwa JeonDong Woon KimCuk-Seong KimPublished in: PloS one (2018)
These results strongly suggest that CRIF1 deficiency promotes endothelial cell inflammation by increasing VCAM-1 expression, elevating inflammatory cytokines levels, and activating the transcription factor NF-κB, all of which were inhibited by SIRT1 overexpression.