SIPA1 Is a Modulator of HGF/MET Induced Tumour Metastasis via the Regulation of Tight Junction-Based Cell to Cell Barrier Function.

Chang LiuWen Guo JiangLijian ZhangRachel HargestTracey A Martin

Published in: Cancers (2021)

SIPA1 plays an essential role in lung tumourigenesis and metastasis. SIPA1 may be a diagnostic and prognostic predictive biomarker. SIPA1 may also be a potential therapeutic target for non-small cell lung cancer (NSCLC) patients with aberrant MET expression and drug resistance.

Keyphrases

single cell
cell therapy
poor prognosis
small cell lung cancer
tyrosine kinase
high glucose
mesenchymal stem cells
drug induced
climate change
human health