Blood Eosinophils in Chinese COPD Participants and Response to Treatment with Combination Low-Dose Theophylline and Prednisone: A Post-Hoc Analysis of the TASCS Trial.
Thomas BradburyGian Luca Di TannaAnish ScariaAllison MartinFu-Qiang WenNan-Shan ZhongJin-Ping ZhengPeter J BarnesBartolome CelliNorbert BerendChristine R Jenkinsnull nullPublished in: International journal of chronic obstructive pulmonary disease (2022)
Combination low-dose theophylline and prednisone was associated with a significant increase in the annual moderate-severe exacerbation rate in participants with a blood eosinophil count ≥300 cells/µL compared to placebo.
Keyphrases
- low dose
- chronic obstructive pulmonary disease
- high dose
- induced apoptosis
- phase iii
- cell cycle arrest
- clinical trial
- study protocol
- early onset
- high intensity
- randomized controlled trial
- phase ii
- double blind
- endoplasmic reticulum stress
- open label
- peripheral blood
- combination therapy
- mechanical ventilation
- extracorporeal membrane oxygenation
- smoking cessation
- chronic rhinosinusitis