A systematic review with meta-analysis of biomarkers for detection of pulmonary arterial hypertension.

A Josien SmitsLiza BotrosMarijke A E MolKirsten A ZiesemerMartin R WilkinsAnton Vonk NoordegraafHarm Jan BogaardJurjan Aman

Published in: ERJ open research (2022)

This meta-analysis validates NT-proBNP as a biomarker with high sensitivity for PAH, albeit with low specificity. The majority of biomarkers evaluated in this meta-analysis lacked either external validation or data on diagnostic accuracy. Further validation studies are required as well as studies that test combinations of biomarkers to improve specificity.

Keyphrases

pulmonary arterial hypertension
case control
systematic review
meta analyses
pulmonary hypertension
electronic health record
randomized controlled trial
machine learning
structural basis
loop mediated isothermal amplification