Monitoring CD8a+ T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [64Cu]NOTA-CD8a PET Imaging.

Lotte K KristensenCamilla ChristensenMaria Z AlfsenSigrid ColdCarsten H NielsenAndreas Kjaer

Published in: Molecular imaging and biology (2021)

In the present study, we demonstrated that [64Cu]NOTA-CD8a was able to detect treatment-induced changes in CD8a+ infiltration in murine CT26 colon tumors following a common preclinical combination treatment protocol. Overall, [64Cu]NOTA-CD8a exhibited good prognostic and predictive value. We suggest that [64Cu]NOTA-CD8a PET imaging can be used as an early biomarker of response to therapy in preclinical models.

Keyphrases

pet imaging
nk cells
randomized controlled trial
squamous cell carcinoma
computed tomography
magnetic resonance imaging
positron emission tomography
magnetic resonance
mesenchymal stem cells
radiation induced
pet ct