Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures.
María Elena SotoIsrael Pérez-TorresMaría Esther Rubio-RuizAgustina Cano-MartínezLinaloe Manzano-PechVerónica Guarner-LansPublished in: International journal of molecular sciences (2023)
Frailty is a global health problem that impacts clinical practice. It is complex, having a physical and a cognitive component, and it is the result of many contributing factors. Frail patients have oxidative stress and elevated proinflammatory cytokines. Frailty impairs many systems and results in a reduced physiological reserve and increased vulnerability to stress. It is related to aging and to cardiovascular diseases (CVD). There are few studies on the genetic factors of frailty, but epigenetic clocks determine age and frailty. In contrast, there is genetic overlap of frailty with cardiovascular disease and its risk factors. Frailty is not yet considered a risk factor for CVD. It is accompanied by a loss and/or poor functioning of muscle mass, which depends on fiber protein content, resulting from the balance between protein breakdown and synthesis. Bone fragility is also implied, and there is a crosstalk between adipocytes, myocytes, and bone. The identification and assessment of frailty is difficult, without there being a standard instrument to identify or treat it. Measures to prevent its progression include exercises, as well as supplementing the diet with vitamin D and K, calcium, and testosterone. In conclusion, more research is needed to better understand frailty and to avoid complications in CVD.
Keyphrases
- cardiovascular disease
- community dwelling
- adipose tissue
- risk factors
- skeletal muscle
- oxidative stress
- global health
- clinical practice
- bone mineral density
- type diabetes
- public health
- insulin resistance
- gene expression
- end stage renal disease
- newly diagnosed
- protein protein
- genome wide
- climate change
- weight loss
- body composition
- peritoneal dialysis
- signaling pathway
- patient reported outcomes
- copy number
- amino acid
- drug induced
- high fat diet induced