Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer.

Wei-Lan YehCheng-Fang TsaiDar-Ren Chen

Published in: Stem cell research & therapy (2017)

Our findings suggest that CXCL1 secreted by hAdSCs elicits doxorubicin resistance through miR-106a-mediated ABCG2 upregulation in triple negative breast cancer. These findings provide a better understanding of the importance of adipose-derived stem cells in breast cancer microenvironment regarding to the development of chemoresistance and reveal the potential of discovering novel therapeutic strategies to overcome drug resistance in TNBC.

Keyphrases

cell proliferation
long non coding rna
stem cells
wound healing
cancer stem cells
drug delivery
poor prognosis
signaling pathway
long noncoding rna
cancer therapy
single cell
dna methylation
climate change