Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rats.
Chih-Chien SungBrian G PollShih-Hua LinAdrian R Murillo-de-OzoresChung-Lin ChouLihe ChenChin-Rang YangMin-Hsiu ChenYu-Juei HsuMark A KnepperPublished in: Journal of the American Society of Nephrology : JASN (2022)
Immediately after establishment of UUO, collecting ducts manifest a stunned state with broad disappearance of mRNAs. Within 3 hours, there is upregulation of immediate early and inflammatory genes and disappearance of the V2 vasopressin receptor, resulting in loss of AQP2 (confirmed by lipopolysaccharide administration). The inflammatory response seen rapidly after UUO establishment may be relevant to both UUO-induced polyuria and long-term development of fibrosis in UUO kidneys.