Neural Stem Cells as Potential Glioblastoma Cells of Origin.
Alba LorasLuis G Gonzalez-BonetJulia L Gutierrez-ArroyoConrado Martinez-CadenasMaria Angeles Marques-TorrejonPublished in: Life (Basel, Switzerland) (2023)
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high rates of invasiveness. Therefore, patients face poor prognosis, and the survival rates remain very low. Previous research states that GBM contains a cell population with stem cell characteristics called glioma stem cells (GSCs). These cells are able to self-renew and regenerate the tumor and, therefore, they are partly responsible for the observed resistance to therapies and tumor recurrence. Recent data indicate that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells of origin of GBM, that is, the cell type acquiring the initial tumorigenic mutation. The involvement of SVZ-NSCs is also associated with GBM progression and recurrence. Identifying the cellular origin of GBM is important for the development of early detection techniques and the discovery of early disease markers. In this review, we analyze the SVZ-NSC population as a potential GBM cell of origin, and its potential role for GBM therapies.
Keyphrases
- stem cells
- induced apoptosis
- neural stem cells
- poor prognosis
- cell cycle arrest
- cell therapy
- long non coding rna
- single cell
- ejection fraction
- oxidative stress
- endoplasmic reticulum stress
- free survival
- cell death
- signaling pathway
- high throughput
- machine learning
- cell proliferation
- electronic health record
- risk assessment
- human health