Molecular characterization of HAMP rs10421768 gene and phenotypic expression of hepcidin; a case-control study among sickle cell anaemia patients in Ghana.

Samuel Kwasi AppiahCharles NkansahGabriel Abbam Felix Osei-BoakyeKofi MensahSimon Bannison BaniSolomon ChemogoLydia SarpongTakyi Godfred AddaeDaniel Boamah SefaRichard Adu CroffienLarry AdomRekhiatu Oboirien Abdul RaufFarrid BoaduGodfred Appiah AmoahEjike Felix Chukwurah

Published in: PloS one (2024)

The HAMP promoter rs10421768 AA genotype has the highest frequency of distribution and the GG genotype with the least distribution. Participants with HAMP rs10421768 G allele (c.-582A>G) had reduced levels of hepcidin. HAMP rs10421768 genotypes had no association with blood cell parameters and disease severity. The HAMP rs10421768 genotypes may influence serum levels of hepcidin. Further study is required to elucidate the potential effect of the G allele on hepcidin transcription.

Keyphrases

iron deficiency
end stage renal disease
newly diagnosed
transcription factor
ejection fraction
dna methylation
poor prognosis
gene expression
single cell
prognostic factors
genome wide
peritoneal dialysis
risk assessment
patient reported outcomes
bone marrow