Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial.
Rano ZhankinaUlanbek BalpukovManarbek AskarovAfshin ZareNazanin JafariDana SaipiyevaRavil SherkhanovDaniyar AkhmetovAlireza HashemiMojtaba FarjamNader TanidehBehrouz AflatoonianNadiar Maratovich MussinAsset Askerovich KaliyevYerlan SultangereyevRaiane Monteiro Clacino MachadoReza ShiraziMahdi MahdipourShabnam BakhshalizadehFarhad RahmanifarAmin TamadonPublished in: International journal of fertility & sterility (2024)
Autotransplantation of BM-MSCs into the testicular network using microTESE in NOA patients led to the regeneration of seminiferous tubules and the regulation of hormonal profiles governing spermatogenesis. Our findings support the safety and effectiveness of autologous BM-MSCs as a promising treatment modality for NOA, with a particular focus on the achieved outcomes in patients with secondary infertility (registration number: IRCT20190519043634N1).
Keyphrases
- stem cells
- bone marrow
- clinical trial
- mesenchymal stem cells
- cell therapy
- end stage renal disease
- ejection fraction
- randomized controlled trial
- polycystic ovary syndrome
- systematic review
- type diabetes
- prognostic factors
- metabolic syndrome
- patient reported outcomes
- skeletal muscle
- body composition
- open label
- insulin resistance
- patient reported
- bone regeneration