By reducing oxidative stress, naringenin mitigates hyperglycaemia-induced upregulation of hepatic nuclear factor erythroid 2-related factor 2 protein.
Lereko KometsiKhmera GovenderEdith P Mofo MatoRajendraparsad HurchundPeter M O OwiraPublished in: The Journal of pharmacy and pharmacology (2020)
Naringenin confers hepatoprotective antioxidant effects by initially preventing upregulation of Nrf2 protein expression and its downstream antioxidant enzymes.
Keyphrases
- oxidative stress
- nuclear factor
- diabetic rats
- toll like receptor
- poor prognosis
- cell proliferation
- ischemia reperfusion injury
- dna damage
- signaling pathway
- induced apoptosis
- high glucose
- anti inflammatory
- long non coding rna
- amino acid
- inflammatory response
- protein protein
- immune response
- endothelial cells
- heat shock
- heat shock protein