IL10 Secretion Endows Intestinal Human iNKT Cells with Regulatory Functions Towards Pathogenic T Lymphocytes.

Claudia Burrello Francesco StratiGeorgia LattanziAngelica Diaz-BasabeErika MiletiMaria Rita GiuffrèGianluca LopezFulvia Milena CribiùElena TrombettaMarinos Kallikourdis Marco CremonesiFrancesco ConfortiFiorenzo BottiLaura PorrettiMaria RescignoMaurizio VecchiMassimo C FantiniFlavio CaprioliFederica Facciotti

Published in: Journal of Crohn's & colitis (2022)

These results describe an unprecedentd IL10-mediated immunoregulatory role of intestinal iNKT cells in controlling the pathogenic functions of mucosal T helper subsets and in maintaining the intestinal immune homeostasis.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
transcription factor
oxidative stress
signaling pathway
regulatory t cells
immune response
cell proliferation
pluripotent stem cells