Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function.
Matthew E BrownPuchong ThirawatananondLeeana D PetersElizabeth J KernSonali VijayLindsey K SachsAmanda L PosgaiMaigan A BruskoMelanie R ShapiroClayton E MathewsRhonda BacherTodd M BruskoPublished in: bioRxiv : the preprint server for biology (2024)
CD226 blockade reduces T cell cytotoxicity and improves Treg function, representing a targeted and rational approach for restoring immune regulation in type 1 diabetes.