Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer.
Shika Hanif MalgundkarYahya TamimiPublished in: Future science OA (2023)
More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.
Keyphrases
- prognostic factors
- mesenchymal stem cells
- epithelial mesenchymal transition
- stem cells
- induced apoptosis
- cell therapy
- cell cycle arrest
- single cell
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- emergency department
- endoplasmic reticulum stress
- transforming growth factor
- poor prognosis
- squamous cell carcinoma
- climate change
- papillary thyroid
- high resolution
- risk assessment
- human health
- lymph node metastasis
- mass spectrometry
- pi k akt