Extracellular matrix and traumatic brain injury.
Naijil GeorgeHerbert M GellerPublished in: Journal of neuroscience research (2018)
The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.
Keyphrases
- extracellular matrix
- traumatic brain injury
- resting state
- white matter
- cerebral ischemia
- single cell
- severe traumatic brain injury
- functional connectivity
- stem cells
- cell therapy
- spinal cord injury
- multiple sclerosis
- mesenchymal stem cells
- brain injury
- subarachnoid hemorrhage
- risk assessment
- climate change
- human health
- mild traumatic brain injury
- wound healing
- childhood cancer