External evaluation of published population pharmacokinetic models of polymyxin B.
Ya-Qian LiKai-Feng ChenJun-Jie DingHong-Yi TanNan YangYa-Qi LinCui-Fang WuYue-Liang XieGuo-Ping YangJing-Jing LiuQi PeiPublished in: European journal of clinical pharmacology (2021)
Not all published models were satisfactory in prediction- and simulation-based diagnostics; however, Bayesian forecasting improved the predictability considerably with priors, which can be applied to guide polymyxin B dosing recommendations and adjustments for clinicians.