Histone variants expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Maryam AsadipourVahideh Hassan ZadehNaheed AryaeianFarhad ShahramMahdi MahmoudiPublished in: International journal of rheumatic diseases (2017)
Given the role of H3.3 and H2A.Z in nucleosome positioning, chromatin structure and transcription regulation, we suggest that lymphocytes and monocytes, the main cell subtypes in PBMCs of RA patients, possess a more accessible chromatin.
Keyphrases
- transcription factor
- end stage renal disease
- dna damage
- gene expression
- ejection fraction
- chronic kidney disease
- genome wide
- poor prognosis
- peripheral blood
- newly diagnosed
- dna methylation
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- stem cells
- dendritic cells
- binding protein
- long non coding rna
- ankylosing spondylitis
- systemic lupus erythematosus
- interstitial lung disease