Unilesional mycosis fungoides is associated with increased expression of microRNA-17~92 and T helper 1 skewing.

Unilesional MF exhibits a microRNA profile distinct from that of conventional early MF, with a higher level of miR-17~92 members along with Th1 skewing. These findings suggest a robust reactive T-cell immune response in unilesional MF and might account for the localized nature of this disease.