Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses.
Niki L DimouNagisa MoriSophia HarlidJustin HarbsRichard M MartinKarl Smith-ByrneNikos PapadimitriouD Timothy BishopGraham CaseySandra M Colorado-YoharMichelle CotterchioAmanda J CrossLoic Le MarchandYi LinKenneth OffitN Charlotte Onland-MoretUlrike PetersJohn D PotterThomas E RohanElisabete WeiderpassMarc J GunterNeil MurphyPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2021)
Our results from large-scale analyses provide little evidence for sex hormone pathways playing a causal role in colorectal cancer development.See related commentary by Hang and Shen, p. 1302.