Adherence, Effectiveness and Safety of Dolutegravir Based Antiretroviral Regimens among HIV Infected Children and Adolescents in Tanzania.
Ritah Francis MutagondaHamu J MlyukaBetty A MagandaAppolinary A R KamuhabwaPublished in: Journal of the International Association of Providers of AIDS Care (2022)
Objectives: This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children and adolescents in Tanzania. Methods: This was a single-center prospective cohort study, conducted at the pediatric HIV Clinic in Mbeya, Tanzania. A binary logistic regression model was used to determine predictors of undetectable viral load at week 24. The results were significant when P-value was <0.05. Results: A total of 200 patients were enrolled with the majority (85.5%) being treatment experienced. High adherence levels (71%) were observed using the pharmacy refill method. At week 24, the overall proportion of patients with undetectable viral load was 70.2%. The predictors of undetectable viral load were age, World Health Organization (WHO) clinical stage, baseline VL and adherence to pharmacy refill. Conclusion: The majority of patients attained undetectable viral load 6 months after using DTG based regimen. DTG-based regimens were generally safe with few ADEs reported.
Keyphrases
- hiv infected
- antiretroviral therapy
- end stage renal disease
- ejection fraction
- newly diagnosed
- human immunodeficiency virus
- hiv infected patients
- hiv positive
- hiv aids
- peritoneal dialysis
- primary care
- randomized controlled trial
- hepatitis c virus
- men who have sex with men
- skeletal muscle
- glycemic control
- weight loss
- south africa
- hiv testing