Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest.
William J MeurerFlorian F SchmitzbergerSharon YeattsViswanathan RamakrishnanBenjamin AbellaTom AufderheideWilliam BarsanJustin BenoitScott BerryJoy BlackNia BozemanKristine BroglioJeremy BrownKimberly BrownNoelle CarlozziAngela CaveneySung-Min ChoHangyul Chung-EsakiRobert ClevengerRobin ConwitRichelle CooperValentina CrudoMohamud DayaDeneil HarneyCindy HsuNicholas J JohnsonImad KhanShaveta KhoslaPeyton KlineAnna KratzPeter KudenchukRoger J LewisChaitra MadiyalSara MeyerJarrod MosierMarwan MouammarMatthew NethBrian O'NeilJames PaxtonSofia PerezSarah PermanCemal SozenerMickie SpeersAimee SpiteriValerie StevensonKavita SunthankarJoseph TonnaScott YoungquistRomergryko GeocadinRobert Silbergleitnull nullPublished in: Trials (2024)
ClinicalTrials.gov NCT04217551. Registered on 30 December 2019.
Keyphrases
- cardiac arrest
- double blind
- cardiopulmonary resuscitation
- clinical trial
- end stage renal disease
- open label
- ejection fraction
- chronic kidney disease
- newly diagnosed
- phase iii
- brain injury
- placebo controlled
- peritoneal dialysis
- diabetic rats
- high glucose
- randomized controlled trial
- oxidative stress
- patient reported outcomes
- cerebral ischemia
- endothelial cells
- patient reported