Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10.

Rosario Hervás-SalcedoMaría Fernández-GarcíaMiriam Hernando-RodríguezOscar Quintana-BustamanteJose-Carlos SegoviaMarcio Alvarez-SilvaMariano García-ArranzPablo MinguezVictoria Del PozoMarta Rodríguez de AlbaDamián García-OlmoCarmen AyusoMaría Luisa LamanaJuan A BuerenRosa María Yañez

Published in: Stem cell research & therapy (2021)

Our results demonstrate that the transient co-expression of CXCR4 and IL10 enhances the therapeutic potential of MSCs in a local inflammation mouse model, suggesting that these mRNA-modified cells may constitute a new step in the development of more efficient cell therapies for the treatment of inflammatory diseases.

Keyphrases

poor prognosis
mouse model
oxidative stress
induced apoptosis
binding protein
cerebral ischemia
mesenchymal stem cells
bone marrow
cell therapy
stem cells
blood brain barrier
endoplasmic reticulum stress
signaling pathway
brain injury
umbilical cord
cell proliferation