Dbx2 regulation in limbs suggests interTAD sharing of enhancers.

Leonardo BeccariGabriel JaquierLucille Lopez-DelisleEddie Rodriguez-CarballoBénédicte MascrezSandra GittoJoost WolteringDenis Duboule

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

We conclude that Hoxa13 and Hoxd genes cooperatively activate Dbx2 expression in developing digits through binding to mammalian specific regulatory sequences in the Dbx2 neighborhood. Furthermore, these enhancers can overcome TAD boundaries in either direction to co-regulate a set of genes located in distinct chromatin domains.

Keyphrases

genome wide
transcription factor
genome wide identification
poor prognosis
bioinformatics analysis
gene expression
long non coding rna
dna damage
physical activity
social media
health information