Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.

Rebecca D DoddAmanda SchererWesley Huang Gavin R McGivney Wade R GutierrezEmily A LavertyKathleen A AshcraftVictoria R StephensParisa YousefpourSoumen SahaVickie Knepper-AdrianWarren FloydMark ChenYan MaEric M MastriaDiana M CardonaWilliam C EwardAshutosh Chilkoti David G Kirsch

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These results have important implications for treating sarcomas with nanoparticle-encapsulated chemotherapy by highlighting the tumor subtype-dependent nature of therapeutic response.

Keyphrases

locally advanced
mouse model
cell therapy
cell proliferation
squamous cell carcinoma
iron oxide
stem cells
chemotherapy induced
signaling pathway