Do Serum Urate-Associated Genetic Variants Differentially Contribute to Gout Risk According to Body Mass Index? Analysis of the UK Biobank.

Vicky TaiRavi K NarangGreg GambleMurray CadzowLisa K StampTony R MerrimanNicola Dalbeth

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

The association of a urate GRS with gout is mildly attenuated in obese individuals compared to overweight individuals. However, genetic variants have a strong effect on gout risk in those with overweight and obese BMIs, with an effect similar to that observed in low/normal BMI.

Keyphrases

body mass index
uric acid
weight gain
weight loss
physical activity
adipose tissue
cross sectional