Effects of Sustained Hyperglycemia on Skeletal Muscle Lipids in Healthy Subjects.

Christopher E ShannonAurora MerovciMarcel FourcaudotDevjit TripathyMuhammad Abdul-GhaniHu WangXianlin HanLuke NortonRalph A DeFronzo

Published in: The Journal of clinical endocrinology and metabolism (2022)

Our results demonstrate that the major lipid pools in skeletal muscle are unperturbed by sustained increases in glucose availability and suggest that glucotoxicity and lipotoxicity drive insulin resistance through distinct mechanistic pathways.

Keyphrases

skeletal muscle
insulin resistance
high fat diet
polycystic ovary syndrome
adipose tissue
fatty acid
high fat diet induced
metabolic syndrome
type diabetes
blood glucose